CBI 5: The Brain is a 2022 Indian Malayalam-language mystery thriller film directed by K. Madhu and written by S. N. Swamy. The film stars Mammootty reprising his role as CBI officer Sethurama Iyer along with an ensemble cast. It is the fifth installment of CBI film series. The soundtrack and score are composed by Jakes Bejoy in his first collaboration with Mammootty. The mixing and mastering of teaser were done by Balu Thankachan. The audio rights for the film were bought by Saina. For the main theme of the film, Jakes recreated the original theme from the first film composed by Shyam.